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A Concise Semisynthesis of Hederagonic Acid

- C–H Activation in Natural Product Synthesis
Af: Christian Knittl-Frank Engelsk Paperback

A Concise Semisynthesis of Hederagonic Acid

- C–H Activation in Natural Product Synthesis
Af: Christian Knittl-Frank Engelsk Paperback
Tjek vores konkurrenters priser
Christian Knittl-Frank reports on the development of a novel synthetic route to the naturally occurring polyhydroxylated oleanane, hederagonic acid. Polyhydroxylated oleananes are a vast family of naturally occurring triterpenoids with versatile biological activities. A low commercial availability combined with high prices make these molecules interesting targets in natural product synthesis. The developed synthetic approach starts from oleanolic acid, a cheap material that is commercially available in bulk quantities. It features several multi-step one-pot reactions, allowing a minimization of the number of steps and reducing the preparative effort. Importantly, catalytic C-H functionalization was achieved at unusually low temperatures. Hederagonic acid was thus prepared in as little as four steps, resulting in the shortest semisynthesis of this oleanane to date.

The Author

Christian Knittl-Frank is currently pursuing his PhD studies, focusing on natural product synthesis and synthetic methodology, at the Department of Organic Chemistry, University of Vienna, Austria. He is part of the MolTag doctoral program that aims to development new molecular drugs targeting ion channels.

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Christian Knittl-Frank reports on the development of a novel synthetic route to the naturally occurring polyhydroxylated oleanane, hederagonic acid. Polyhydroxylated oleananes are a vast family of naturally occurring triterpenoids with versatile biological activities. A low commercial availability combined with high prices make these molecules interesting targets in natural product synthesis. The developed synthetic approach starts from oleanolic acid, a cheap material that is commercially available in bulk quantities. It features several multi-step one-pot reactions, allowing a minimization of the number of steps and reducing the preparative effort. Importantly, catalytic C-H functionalization was achieved at unusually low temperatures. Hederagonic acid was thus prepared in as little as four steps, resulting in the shortest semisynthesis of this oleanane to date.

The Author

Christian Knittl-Frank is currently pursuing his PhD studies, focusing on natural product synthesis and synthetic methodology, at the Department of Organic Chemistry, University of Vienna, Austria. He is part of the MolTag doctoral program that aims to development new molecular drugs targeting ion channels.

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Produktdetaljer
Sprog: Engelsk
Sider: 60
ISBN-13: 9783658300104
Indbinding: Paperback
Udgave:
ISBN-10: 3658300108
Kategori: Katalyse
Udg. Dato: 7 apr 2020
Længde: 0mm
Bredde: 148mm
Højde: 210mm
Forlag: Springer Fachmedien Wiesbaden
Oplagsdato: 7 apr 2020
Forfatter(e): Christian Knittl-Frank
Forfatter(e) Christian Knittl-Frank

Kategori Katalyse

ISBN-13 9783658300104

Sprog Engelsk

Indbinding Paperback

Sider 60

Udgave

Længde 0mm

Bredde 148mm

Højde 210mm

Udg. Dato 7 apr 2020

Oplagsdato 7 apr 2020

Forlag Springer Fachmedien Wiesbaden

Kategori sammenhænge