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  1. Bog
  2. Klinisk & Intern medicin
  3. Hepatologi

AMPK-S6K1 Signaling Pathway as a Target for Treating Hepatic Insulin Resistance

Af: Sang Geon Kim, Hee Yeon Kay, Je Cho Engelsk Paperback

AMPK-S6K1 Signaling Pathway as a Target for Treating Hepatic Insulin Resistance

Af: Sang Geon Kim, Hee Yeon Kay, Je Cho Engelsk Paperback
Tjek vores konkurrenters priser
Hepatic insulin resistance and altered insulin metabolism, as characterised by the desensitisation of hepatic parenchymal cells to insulin, play a role in the pathogenesis of liver disease, particularly resulting in steatosis and steatohepatitis. By the same token, type II diabetic patients are at higher risk for developing liver diseases, including steatosis, hepatitis, cirrhosis, and hepatocellular carcinoma. On the other hand, established liver disease from any cause leads to glucose intolerance and peripheral insulin resistance systemically. The link between insulin resistance and liver pathology reviewed in this book suggests that insulin resistance is closely related with a variety of liver diseases. Recent evidence indicates that the AMP activating protein kinase (AMPK) in conjunction with p70 ribosomal S6 kinase 1 (S6K1) serves as a key signalling pathway regulating insulin-dependent physiological functions; thus, this pathway serves as a target for the therapy of diseases associated with insulin resistance. In this chapter, the regulatory role of the AMPK-S6K1 pathway is discussed in terms of enhancing insulin receptor signalling with insulin receptor substrate-1/2 and phosphatidylinositol phosphate kinase activity, which may contribute to preventing and/or treating insulin resistance in the liver.
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Hepatic insulin resistance and altered insulin metabolism, as characterised by the desensitisation of hepatic parenchymal cells to insulin, play a role in the pathogenesis of liver disease, particularly resulting in steatosis and steatohepatitis. By the same token, type II diabetic patients are at higher risk for developing liver diseases, including steatosis, hepatitis, cirrhosis, and hepatocellular carcinoma. On the other hand, established liver disease from any cause leads to glucose intolerance and peripheral insulin resistance systemically. The link between insulin resistance and liver pathology reviewed in this book suggests that insulin resistance is closely related with a variety of liver diseases. Recent evidence indicates that the AMP activating protein kinase (AMPK) in conjunction with p70 ribosomal S6 kinase 1 (S6K1) serves as a key signalling pathway regulating insulin-dependent physiological functions; thus, this pathway serves as a target for the therapy of diseases associated with insulin resistance. In this chapter, the regulatory role of the AMPK-S6K1 pathway is discussed in terms of enhancing insulin receptor signalling with insulin receptor substrate-1/2 and phosphatidylinositol phosphate kinase activity, which may contribute to preventing and/or treating insulin resistance in the liver.
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Produktdetaljer
Sprog: Engelsk
Sider: 59
ISBN-13: 9781608766932
Indbinding: Paperback
Udgave:
ISBN-10: 1608766934
Kategori: Hepatologi
Udg. Dato: 21 maj 2010
Længde: 5mm
Bredde: 152mm
Højde: 224mm
Forlag: Nova Science Publishers Inc
Oplagsdato: 21 maj 2010
Forfatter(e): Sang Geon Kim, Hee Yeon Kay, Je Cho
Forfatter(e) Sang Geon Kim, Hee Yeon Kay, Je Cho

Kategori Hepatologi

ISBN-13 9781608766932

Sprog Engelsk

Indbinding Paperback

Sider 59

Udgave

Længde 5mm

Bredde 152mm

Højde 224mm

Udg. Dato 21 maj 2010

Oplagsdato 21 maj 2010

Forlag Nova Science Publishers Inc

Kategori sammenhænge