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Clinical Pharmacokinetic and Pharmacodynamic Drug Interactions Associated with Antimalarials
Engelsk Paperback

Clinical Pharmacokinetic and Pharmacodynamic Drug Interactions Associated with Antimalarials

Engelsk Paperback

419 kr
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Om denne bog

This comprehensive review provides a systematic, unbiased analysis, critique and summary of the available literature and generates novel clinical decision-making algorithms which can aid clinicians and scientists in practice management and research development. Potential mechanisms for the identified drug interactions are deduced from available preclinical and in vitro data which are interpreted in the context of the in vivo findings. Current limitations and gaps in the literature are summarized, and potential future research directions / experimentations are also suggested. In addition to the main objective to review the available clinical pharmacokinetic and pharmacodynamic drug interactions associated with WHO-recommended antimalarial drugs on the market today (i.e. chloroquine, amodiaquine, sulfadoxine, pyrimethamine, mefloquine, artemisinin, artemether, artesunate, dihydroartemisinin, artemotil, lumefantrine, primaquine, atovaquone, proguanil, piperaquine and quinine), this book also provides succinct chapter summaries on the epidemiology of malaria infection, diagnosis and therapeutics, in vivo pharmacology and chemistry, preclinical pharmacology, in vitro pharmacodynamics, in vitro reaction phenotyping, and in vitro drug-drug interaction data associated with the identified antimalarial drugs.

Product detaljer
Sprog:
Engelsk
Sider:
146
ISBN-13:
9783319381930
Indbinding:
Paperback
Udgave:
ISBN-10:
3319381938
Kategori:
Udg. Dato:
23 aug 2016
Længde:
0mm
Bredde:
155mm
Højde:
235mm
Forlag:
Springer International Publishing AG
Oplagsdato:
23 aug 2016
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