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DNA Systems Under Internal and External Forcing

- An Exploration Using Coarse-Grained Modelling
Af: Megan Clare Engel Engelsk Paperback

DNA Systems Under Internal and External Forcing

- An Exploration Using Coarse-Grained Modelling
Af: Megan Clare Engel Engelsk Paperback
Tjek vores konkurrenters priser
The interactions of DNA with force are central to manifold fields of inquiry, including the de novo design of DNA nanostructures, the use of DNA to probe the principles of biological self-assembly, and the operation of cellular nanomachines. This work presents a survey of three distinct ways coarse-grained simulations can help characterize these interactions. A non-equilibrium energy landscape reconstruction technique is validated for use with the oxDNA model and a practical framework to guide future applications is established. A novel method for calculating entropic forces in DNA molecules is outlined and contrasted with existing, flawed approaches. Finally, a joint experimental-simulation study of large DNA origami nanostructures under force sheds light on design principles and, through vivid illustrations, their unfolding process. This text provides an accessible and exciting launching point for any student interested in the computational study of DNA mechanics and force interactions.
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The interactions of DNA with force are central to manifold fields of inquiry, including the de novo design of DNA nanostructures, the use of DNA to probe the principles of biological self-assembly, and the operation of cellular nanomachines. This work presents a survey of three distinct ways coarse-grained simulations can help characterize these interactions. A non-equilibrium energy landscape reconstruction technique is validated for use with the oxDNA model and a practical framework to guide future applications is established. A novel method for calculating entropic forces in DNA molecules is outlined and contrasted with existing, flawed approaches. Finally, a joint experimental-simulation study of large DNA origami nanostructures under force sheds light on design principles and, through vivid illustrations, their unfolding process. This text provides an accessible and exciting launching point for any student interested in the computational study of DNA mechanics and force interactions.
Produktdetaljer
Sprog: Engelsk
Sider: 144
ISBN-13: 9783030254155
Indbinding: Paperback
Udgave:
ISBN-10: 3030254151
Udg. Dato: 28 sep 2020
Længde: 0mm
Bredde: 155mm
Højde: 235mm
Forlag: Springer Nature Switzerland AG
Oplagsdato: 28 sep 2020
Forfatter(e): Megan Clare Engel
Forfatter(e) Megan Clare Engel


Kategori Kondenserede fasers fysik: væskeform og faststoffysik


ISBN-13 9783030254155


Sprog Engelsk


Indbinding Paperback


Sider 144


Udgave


Længde 0mm


Bredde 155mm


Højde 235mm


Udg. Dato 28 sep 2020


Oplagsdato 28 sep 2020


Forlag Springer Nature Switzerland AG

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