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Human Papillomavirus (HPV) Involvement in Esophageal Carcinogensis
Engelsk Paperback
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Human Papillomavirus (HPV) Involvement in Esophageal Carcinogensis

Engelsk Paperback

654 kr
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Om denne bog
Esophageal squamous cell carcinoma (SCC) has a peculiar geographical distribution, with up to 500-fold variations in incidence between the low- and high-risk regions. The first reports suggesting HPV involvement in both benign and malignant squamous cell tumours of the oesophagus date back to 1982. The rapidly increasing literature on this subject is summarised in this book. Screening studies in high-incidence areas of China using balloon cytology sampling report high prevalence of HPV DNA among asymptomatic subjects, followed by HPV DNA detection in hyperplastic and dysplastic epithelia adjacent to SCC. There are close human parallels to both SCP and SCC in the cattle, linked with BPV4 and alimentary carcinogens (bracken fern). In vitro experiments on HPV-positive cancer cell lines implicate similar molecular mechanisms as involved e.g. in HPV-associated genital carcinogenesis. Taken together, these data suggest that the (multifactorial) etiology of oesophageal cancer differs between the low- and high-incidence geographical areas. Oncogenic HPV types seem to play an important causal role only in the high-incidence regions.
Product detaljer
Sprog:
Engelsk
Sider:
96
ISBN-13:
9781608762118
Indbinding:
Paperback
Udgave:
ISBN-10:
1608762114
Kategori:
Udg. Dato:
19 aug 2010
Længde:
8mm
Bredde:
156mm
Højde:
231mm
Forlag:
Nova Science Publishers Inc
Oplagsdato:
19 aug 2010
Forfatter(e):
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