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Myths And Verities In Protein Folding Theories

Af: Arieh Ben-naim Engelsk Paperback

Myths And Verities In Protein Folding Theories

Af: Arieh Ben-naim Engelsk Paperback
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This book tells the story of a whole field of research which went disastrously wrong in many different directions when the wrong tools were used and the wrong targets aimed at, to solve a problem.

It all started from the misinterpretation of Schellman's experiments which were carried out in the mid-1950s, and which were later encapsulated by the so-called "Hydrogen-bond inventory argument." As a result, hydrogen bonding was ignored in protein folding; along with that a whole repertoire of other possible hydrophilic effects were not even considered. Against this background the hydrophobic effects, as suggested by Kauzmann, became the single most important effects in protein folding.

In addition, as a result of the misinterpretation of Anfinsen's hypothesis, as well as misunderstanding of the Second Law, people made futile attempts to search for the structure of proteins in the global minimum of either the Energy, or the Gibbs Energy Landscape.

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This book tells the story of a whole field of research which went disastrously wrong in many different directions when the wrong tools were used and the wrong targets aimed at, to solve a problem.

It all started from the misinterpretation of Schellman's experiments which were carried out in the mid-1950s, and which were later encapsulated by the so-called "Hydrogen-bond inventory argument." As a result, hydrogen bonding was ignored in protein folding; along with that a whole repertoire of other possible hydrophilic effects were not even considered. Against this background the hydrophobic effects, as suggested by Kauzmann, became the single most important effects in protein folding.

In addition, as a result of the misinterpretation of Anfinsen's hypothesis, as well as misunderstanding of the Second Law, people made futile attempts to search for the structure of proteins in the global minimum of either the Energy, or the Gibbs Energy Landscape.

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Se mere i:
Produktdetaljer
Sprog: Engelsk
Sider: 448
ISBN-13: 9789814725996
Indbinding: Paperback
Udgave:
ISBN-10: 9814725994
Kategori: Molekylærbiologi
Udg. Dato: 24 feb 2016
Længde: 23mm
Bredde: 230mm
Højde: 154mm
Forlag: World Scientific Publishing Co Pte Ltd
Oplagsdato: 24 feb 2016
Forfatter(e): Arieh Ben-naim
Forfatter(e) Arieh Ben-naim

Kategori Molekylærbiologi

ISBN-13 9789814725996

Sprog Engelsk

Indbinding Paperback

Sider 448

Udgave

Længde 23mm

Bredde 230mm

Højde 154mm

Udg. Dato 24 feb 2016

Oplagsdato 24 feb 2016

Forlag World Scientific Publishing Co Pte Ltd

Kategori sammenhænge