This book delves into both traditional and modern analytical techniques utilized in the preparation of samples for the extraction, clean-up, detection, and estimation of pesticide residues in soil, water, and food commodities. It also covers some aspects of the Quenchers methods, which are a type of extraction cum clean-up technique. The book provides a brief history of pesticide development, as well as information on modern pesticides and the metabolic pathway of selected xenobiotics from different groups of pesticides. It discusses the latest analytical techniques, including TLC, GLC, HPLC, HPTLC, supercritical extraction, and chromatography, in a clear and concise manner. The book details the sampling, extraction, clean-up, and solid phase extraction techniques for residue analysis, as well as the recently developed multi-residue methods. The book has been updated with the help of numerous standard reference books and research papers, giving it a contemporary feel. Additionally, the book contains a glossary of pesticide residue terms, which can be incredibly helpful for beginners in this field. This book is an excellent resource for students seeking a comprehensive understanding of pesticides, their metabolism, and the various techniques used to estimate residues of toxic xenobiotics in all components of the environment. Overall, it is an excellent read for anyone interested in the field of pesticides and will prove highly valuable to researchers and professionals working in this area.