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Tumor Suppressor Genes in Breast Cancer
Engelsk Paperback
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Tumor Suppressor Genes in Breast Cancer

Engelsk Paperback

536 kr
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Om denne bog
Breast cancer is characterised by the accumulation of genetic alterations, including point mutations and loss of entire DNA regions ("loss of heterozygosity" or LOH). Among genes that are affected by such events, the "tumour suppresser genes" (TSGs) have a peculiar interest since they often occupy pivotal positions in regulatory networks that control the cell cycle and/or encompass various signal transduction cascades. While a number of genes have been suggested as candidate TSGs in breast cancer, only a few of them have been confirmed in this status. They include TP53, BRCA1, BRCA2...and are mainly involved in the control of DNA repair, cell proliferation, apoptosis and signalling. Some TSGs are linked to familial (hereditary) forms of breast cancer. The exact definition of what is a TSG is still debated. Recently, genes not affected by mutation or even LOH, but occasionally methylated have been considered as TSGs.
Product detaljer
Sprog:
Engelsk
Sider:
114
ISBN-13:
9781604563269
Indbinding:
Paperback
Udgave:
ISBN-10:
1604563265
Kategori:
Udg. Dato:
1 jul 2008
Længde:
5mm
Bredde:
154mm
Højde:
224mm
Forlag:
Nova Science Publishers Inc
Oplagsdato:
1 jul 2008
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