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Design and Analysis of Non-Inferiority Trials
Engelsk
Bogcover for Design and Analysis of Non-Inferiority Trials af Brian L. Wiens, Ivan S.F. Chan, Mark D. Rothmann, 9780367576912
Specifikationer
Sprog:
Engelsk
Sider:
454
ISBN-13:
9780367576912
Indbinding:
Paperback
ISBN-10:
0367576910
Kategori:
Udg. Dato:
30 jun 2020
Størrelse i cm:
23,4 x 15,6
Oplagsdato:
30 jun 2020

Design and Analysis of Non-Inferiority Trials

Engelsk
Paperback 2020
Format:

Bog beskrivelse

The increased use of non-inferiority analysis has been accompanied by a proliferation of research on the design and analysis of non-inferiority studies. Using examples from real clinical trials, Design and Analysis of Non-Inferiority Trials brings together this body of research and confronts the issues involved in the design of a non-inferiority trial. Each chapter begins with a non-technical introduction, making the text easily understood by those without prior knowledge of this type of trial.

Topics covered include:

  • A variety of issues of non-inferiority trials, including multiple comparisons, missing data, analysis population, the use of safety margins, the internal consistency of non-inferiority inference, the use of surrogate endpoints, trial monitoring, and equivalence trials
  • Specific issues and analysis methods when the data are binary, continuous, and time-to-event
  • The history of non-inferiority trials and the design and conduct considerations for a non-inferiority trial
  • The strength of evidence of an efficacy finding and how to evaluate the effect size of an active control therapy
  • A comprehensive discussion on the purpose and issues involved with non-inferiority trials, Design and Analysis of Non-inferiority Trials will assist current and future scientists and statisticians on the optimal design of non-inferiority trials and in assessing the quality of non-inferiority comparisons done in practice.

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Specifikationer
Sprog:
Engelsk
Sider:
454
ISBN-13:
9780367576912
Indbinding:
Paperback
ISBN-10:
0367576910
Kategori:
Udg. Dato:
30 jun 2020
Størrelse i cm:
23,4 x 15,6
Oplagsdato:
30 jun 2020
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