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Permutation Testing for Isotonic Inference on Association Studies in Genetics
Engelsk
Bogcover for Permutation Testing for Isotonic Inference on Association Studies in Genetics af Livio Corain, Rosa Arboretti, Dario Mazzaro, Luigi Salmaso, 9783642205835
Specifikationer
Sprog:
Engelsk
Sider:
72
ISBN-13:
9783642205835
Indbinding:
Paperback
ISBN-10:
3642205836
Udg. Dato:
9 jul 2011
Størrelse i cm:
23,5 x 15,5
Oplagsdato:
9 jul 2011

Permutation Testing for Isotonic Inference on Association Studies in Genetics

Engelsk
Paperback 2011
Format:

Bog beskrivelse

The purpose of this book is to illustrate a new statistical approach to test allelic association and genotype-specific effects in the genetic study of diseases. There are some parametric and non-parametric methods available for this purpose. We deal with population-based association studies, but comparisons with other methods will also be drawn, analysing the advantages and disadvantages of each one, particularly with regard to power properties with small sample sizes. In this framework we will work out some nonparametric statistical permutation tests and likelihood-based tests to perform case-control analyses to study allelic association between marker, disease-gene and environmental factors. Permutation tests, in particular, will be extended to multivariate and more complex studies, where we deal with several genes and several alleles together. Furthermore, we show simulations under different assumptions on the genetic model and analyse real data sets by simply studying one locus with the permutation test.

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Specifikationer
Sprog:
Engelsk
Sider:
72
ISBN-13:
9783642205835
Indbinding:
Paperback
ISBN-10:
3642205836
Udg. Dato:
9 jul 2011
Størrelse i cm:
23,5 x 15,5
Oplagsdato:
9 jul 2011
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