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Therapeutic Targeting of RAS Mutant Cancers
Engelsk
Bogcover for Therapeutic Targeting of RAS Mutant Cancers af Edward C. Stites, Shumei Kato, Kendra Paskvan, 9781009073646
Specifikationer
Sprog:
Engelsk
Sider:
75
ISBN-13:
9781009073646
Indbinding:
Paperback
ISBN-10:
1009073648
Kategori:
Udg. Dato:
15 sep 2022
Størrelse i cm:
15,1 x 22,9 x 0,8
Oplagsdato:
15 sep 2022

Therapeutic Targeting of RAS Mutant Cancers

Engelsk
Paperback 2022
Format:

Bog beskrivelse
The KRAS oncogene is believed to be the most common single nucleotide variant oncogene in human cancer. Historically, efforts to target KRAS and the other RAS GTPases have struggled. More recently, efforts have focused on identifying and exploiting features unique to specific oncogenic mutations. This has led to the first FDA approval for a RAS targeted therapy. This new agent is a covalent inhibitor that reacts with the cysteine residue created by a codon 12 glycine to cysteine (G12C) mutation within KRAS. Mutant-specific strategies may also exist for other KRAS single nucleotide variants, and recent studies provide examples and mechanisms.
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Specifikationer
Sprog:
Engelsk
Sider:
75
ISBN-13:
9781009073646
Indbinding:
Paperback
ISBN-10:
1009073648
Kategori:
Udg. Dato:
15 sep 2022
Størrelse i cm:
15,1 x 22,9 x 0,8
Oplagsdato:
15 sep 2022
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